[syndicated profile] ucsdhealthsciences_feed
TitleTag: Harnessing Cancer’s Methylation Footprint for More Precise Diagnosis and Prognosis
News_release:

​In a new study, published online in the July 26 issue of PNAS, researchers at University of California San Diego School of Medicine, with colleagues in Xijing Hospital and Sun Yat-sen Cancer Center in China, report that DNA methylation can provide effective markers for at least four major cancers, not only correctly differentiating malignant tissues from normal, but also providing information on prognosis and survival.

DNA graphic

DNA methylation occurs when methyl groups — one carbon atom bonded to three hydrogen atoms — attach to DNA molecules, changing gene function without changing DNA sequence.

“Choosing the proper cancer treatment with the best chance of recovery and survival depends greatly upon accurately diagnosing the specific type or subtype of cancer,” said Kang Zhang, MD, PhD, founding director of the Institute for Genomic Medicine and co-director of biomaterials and tissue engineering at the Institute of Engineering in Medicine, both at UC San Diego School of Medicine. “If you can do that using a minimally invasive biopsy, it has significant implications for cancer science and medicine. Using DNA methylation markers may be a new and more effective a way forward.”

DNA methylation involves methyl groups — one carbon atom bonded to three hydrogen atoms — attaching to DNA molecules. It is a fundamental epigenetic process that regulates gene function without changing the DNA sequence of a gene, essential to normal development and associated with numerous key processes, including initiation and progression of cancer.

Zhang and colleagues looked at DNA methylation for differentiating tumor tissue and normal tissue for the four most common cancers (lung, breast, colon and liver) in three different databases: a training cohort of 1,619 tumor samples and 173 matched adjacent normal tissue samples; a testing cohort of 791 tumor samples from The Cancer Genome Atlas and 93 matched adjacent normal tissue samples and another independent testing Chinese cohort of 394 tumor samples; and 324 matched adjacent normal tissue samples.

They found that DNA methylation analysis could predict cancer versus normal tissue with more than 95 percent accuracy in the three cohorts, comparable to typical diagnostic methods, according to Zhang. 

In addition, the analysis correctly identified 97 percent colorectal cancer metastases to the liver and 94 percent colorectal cancer metastases to the lung. “Since 10 percent of cancers present as metastatic lesions or cancers of unknown primary origin, identification of tissue of origin is critical for choosing a correct therapy. This new simple method will be of great value to pinpoint the primary source of the tumor,” said Michael Karin, co-senior author of the study and Distinguished Professor of Pharmacology, also at UC San Diego School of Medicine. 

Zhang suggested DNA methylation has the potential to improve outcomes by providing more accurate diagnoses, particularly of relatively indolent or aggressive tumors that may require more or less aggressive treatment.

“Although we focused on just four common cancers here, we expect that DNA methylation analysis could be easily expanded to aid diagnoses of a much larger number of cancers,” said Zhang. “A great benefit is that this approach requires only a small amount of tissue to obtain adequate DNA for analysis, potentially allowing the use of less invasive biopsies or biopsies of metastatic lesions where the tumor is of unknown primary cancer type.”

He said more studies have been planned to fully explore the clinical applications and potential of DNA methylation and its role in future personalized cancer care.

Co-authors include: Xiaoke Hao, Fourth Military Medical University, Xi’an, China; Huiyan Luo and Rui-hua Xu, Sun Yat-sen University Cancer Center, Guangzhou, China; Michal Krawczyk, Wei Wei, Ken Flagg, Jiayi Hou, Shaohua Yi, Maryam Jafari, Danni Lin, Christopher Chung, Bennett A. Caughey, William Shi, Jie Zhu, Xin Fu, Edward Zhang, Charlotte Zhang, and Debanjan Dhar, UC San Diego; Heng Zhang, Lianghong Zheng, and Rui Hou, Chinese Academy of Sciences, Shanghai, China; and Gen Li and Liang Zhao, Guangzhou Youze Biological Pharmaceutical Technology Company, Guangzhou, China.

Funding for this research came, in part, from the Carol and Dick Hertzberg Fund, the Richard Annesser Fund and the Michael Martin Fund.

News_Release_Date: June 27, 2017
[syndicated profile] slacktivist_feed

Posted by Fred Clark

Kelly J. Baker studied one of the darker corners of American history, writing Gospel According to the Klan: The KKK’s Appeal to Protestant America, 1915-1930. Baker wishes this was simply the esoteric specialty of a historian, but her topic of study remains disturbingly relevant today. She’s written about that continuing relevance in a Religion & Culture [Read More...]

Sydney January 2007 3/11

Jun. 27th, 2017 08:16 pm
turlough: Gerard Way & Ray Toro, onstage autumn 2010 ((mcr) gerard and ray rocking out)
[personal profile] turlough posting in [community profile] mychemicalromance_daily
Even more pics from their performance at the Sydney Showground in Sydney, Australia, on 25 January 2007.

Teaser:
MCR

This way... )
laurel: Picture of Laurel with Garibaldi cardboard standup (Default)
[personal profile] laurel
Hey look, it's [personal profile] kevingaustin! (My husband, who rarely posts things, but showed up because I pointed out I was posting here from time to time. Some of you know him and may want to grant access and/or subscribe to him.)

Golden Hill

Jun. 27th, 2017 06:32 pm
tealin: (Default)
[personal profile] tealin


To my great bafflement, it has taken this long for Golden Hill to be released in the US – a multi-award winning highly readable romp through colonial New York, you’d think it’d be obvious, but there you go.

Anyway, here is the main character, Mr. Smith – I roughed these out last year when I read the book, but have only just made them as pretty as I’d like.

Do give Golden Hill a shot if you like
  • fun
  • peril
  • interesting characters
  • meticulous research
  • very satisfying historical fix-it fic

Mr Smith is superficially similar to Moist von Lipwig, which made it a little difficult for me to get a grip on the book at first, because I couldn't see into his head as clearly as Moist's (whose internal world is what really sells the book, IMO), but boy oh boy that was totally worth it for the sake of saving the reveal for the end – the sort of reveal that makes the re-read at least as satisfying as the first.

I don't know about you, but I find most of my recreational reading these days ends up being very serious news and commentary about how much of a mess we're in. It's nice to get a break like this and lose yourself in another time and place, without being devoid of meaning.

Supplemental material – including a rather comprehensive catalogue of 18th-century slang – can be found on the book’s Tumblr.

#resist spreadsheet

Jun. 27th, 2017 01:41 pm
executrix: (Default)
[personal profile] executrix posting in [community profile] thisfinecrew
Spreadsheet of actions fighting AHCA/BCRA; you can add your own group's actions to the spreadsheet:

https://docs.google.com/spreadsheets/d/1TxjyXhCxst8HgqZZym4iXIRirWJs16Qar5AnEr4fy0o/edit?usp=sharing
newredshoes: midcentury modern swallow (<3 | circumnavigator)
[personal profile] newredshoes
Okay. Okay, this thing that I've been pouring hours into for more than month -- it's here. It's finally live. I am so proud of it. I am already thrilled and overwhelmed by its reception!! It definitely started with a late-night annoyed tweet, and now it's a 2,000-word examination of how and why we form and curate cultural memory. Thanks, Wonder Woman!

"Why Do So Few Hollywood Movies Take Place During WWI?" - Pacific Standard (a very big deal!!)
Going to the movies became a ubiquitous means of participating in patriotic culture closer to World War II. The Great Depression halted most memorial-building in its tracks, as memorials required huge local investments. In the 1910s, when movie palaces were still new, they became sites of moral panic for civic and community leaders concerned about sexual looseness and the corruption of American youth, even as only about one-third of the total population attended each week. However, by the 1920s, that number rose to half, and, by the 1930s, two-thirds of Americans took weekly trips to the movies. During WWII, studios supplied hundreds of fictional films torn from the headlines.

Simple, hagiographic narratives about the war predominated. In titles like So Proudly We Hail! (1943), Hell Is for Heroes (1962), and Saving Private Ryan (1999), WWII was "the good war," waged by the U.S. to crush fascism and imperialism. Hollywood did work closely with the War Department to produce pro-war documentaries during the war. But, historically, even films that are not government-funded, or those that have questioned American wars, have largely refused to condemn those who fight it. It is perhaps easier for film studios to sell a vision of Americans as principled heroes fending off all-threatening evil, rather than naïve young men fighting in a conflict of ambiguous nobility.
There's so much more! I got to talk to some amazing people! My job doesn't pay bupkis but the work can be so good!! (And if you feel inclined to share, you can credit me at [twitter.com profile] ejbergdahl.)

Eobard Thawne too

Jun. 27th, 2017 06:05 pm
beccaelizabeth: my Watcher tattoo in blue, plus Be in red Buffy style font (Default)
[personal profile] beccaelizabeth
Just rewatched the season one ep with Mardon and the tsunami.
Thawne is such a dick.
Read more... )

(no subject)

Jun. 27th, 2017 12:07 pm
sheafrotherdon: (Default)
[personal profile] sheafrotherdon
Today is PTSD Awareness Day! Do you have questions about PTSD that you've been afraid to ask? Wondered about stuff that you couldn't find an answer to online? Been curious about something? Feel free to ask me - I am so, so happy to talk about everything I know about PTSD. ♥
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[personal profile] ffutures
https://bundleofholding.com/presents/MutantChronicles

"The Solar System is a roaring mayhem of death and war. The Earth has been swept clean by the violent onslaught of the Dark Legion's monstrous hordes and Undead Legionaries. In the enormous cities of Venus, Mars, and the Outer Planets, heretics devoted to destruction stalk gloomy alleys, spreading their teachings of greed, jealously, and war. With technology failing due to the insidious effects of the Dark Symmetry, humanity must fight the Dark Legion while dealing with infighting and conspiracy from within.

Mutant Chronicles is a full-throttle dieselpunk techno-fantasy RPG, a thrill ride across a Solar System beset by megacorporate intrigue and the invasion of a terrible alien force. Originally published in 1993 by the Swedish company Target Games (now Paradox Entertainment), Mutant Chronicles grew into a franchise, with a Doom Trooper trading card game, three boardgames, a video game, the massive Warzone miniatures game, and two editions of an RPG. More recently there was a 2008 film, a pre-painted miniatures game from Fantasy Flight Games and, last year, a reboot of Warzone by Prodos Games.

In a successful January 2014 Kickstarter campaign, Modiphius Entertainment funded a licensed Third Edition of the Mutant Chronicles RPG and a full support line. The new version uses a fast-playing, cinematic "2d20" system designed by Jay Little (Star Wars: Edge of the Empire). The same system powers the new Modiphius Conan RPG and its forthcoming Star Trek game.

This all-new offer presents the complete 496-page Mutant Chronicles Third Edition corebook along with many faction guides and the Dark Symmetry Campaign. We provide each ebook complete in .PDF (Portable Document Format). Like all Bundle of Holding titles, these books have NO DRM (Digital Restrictions Management), and our customers are entitled to move them freely among all their ereaders.

Ten percent of each purchase (after gateway fees) goes to the charity chosen by Chris Birch of Modiphius Entertainment, Vision Rescue. "Modiphius has chosen to support Vision Rescue through a number of different projects," says Chris. "Our goal is to raise US$20,000 for a Vision Rescue Bus."

The total retail value of the titles in this offer at launch is US$119. Customers who pay just US$12.95 get all four titles in our Starter Collection (retail value $52) as DRM-free .PDF ebooks, including the complete 496-page Mutant Chronicles Third Edition rulebook (retail price $20), the Mutant Chronicles Player's Guide extracted from it (retail $10), and two faction books about the megacorporate nation-states of the Solar System: Capitol Source Book (retail $9.50) and Imperial Source Book (retail $12.50).

Those who pay more than the threshold (average) price, which is set at $19.95 to start, also get our entire Bonus Collection with five more titles worth an additional $67, including the Dark Symmetry Campaign (retail $15) that covers the setting's calamitous early history, and the Bauhaus, Mishima, Cybertronic, and Brotherhood Source Books (retail $13 apiece)."

At least one more title will be added after launch. "When a title is added after launch, ALL customers who previously purchased the bundle automatically receive the newly added title, REGARDLESS of whether or not they paid more than average. This is their reward for buying early."


I'll be honest, I'm pretty sure this isn't my sort of game, and I probably won't be checking it out, but as with all these bundles it looks like you get a lot for your money.

Just One Thing (27 June 2017)

Jun. 27th, 2017 06:01 pm
hollymath: (Default)
[personal profile] hollymath posting in [community profile] awesomeers
It's challenge time!

Comment with Just One Thing you've accomplished in the last 24 hours or so. It doesn't have to be a hard thing, or even a thing that you think is particularly awesome. Just a thing that you did.

Feel free to share more than one thing if you're feeling particularly accomplished!

Extra credit: find someone in the comments and give them props for what they achieved!

Nothing is too big, too small, too strange or too cryptic. And in case you'd rather do this in private, anonymous comments are screened. I will only unscreen if you ask me to.

Go!

best hot fudge sauce

Jun. 27th, 2017 03:54 pm
[syndicated profile] smittenkitchen_feed

Posted by deb

There are a lot of good reasons to put two small jars of homemade hot fudge sauce in your fridge in approximately 10 minutes and possibly forever:
• Hot fudge sauce is the easiest thing on earth to make, and absolutely nothing from a squeeze bottle compares. Not even the stuff at local ice cream parlors, even the kinds that boast about ingredient origins and write their menus on chalkboard walls, are the same. I’m still grumpy about the time I was a gazillion months pregnant ordered hot fudge sauce and someone poured chocolate syrup over my ice cream. I resisted, however, waddling back there and showing them how to make it correctly. I’m sorry I do not behave as well with you.

what you'll needeverything in the potmelt everythingdone!best hot fudge saucebest hot fudge sauce

• Proper hot fudge sauce is thick and shiny. You pour it over a scoop of ice cream and it quickly slides down the sides to form a fudge moat that scoop onto your spoon along with the melty ice cream around it and it’s intensely chocolaty and downright chewy and never gets old.
• It keeps forever, or at least for the remainder of the summer, even if it probably won’t survive that long.
• No matter how many times you rewarm it (we usually spoon a little in to a dish and microwave it for 10 seconds) and chill it again, it never splits or becomes grainy. It remains rich, shiny, and forgiving.
• It makes amazing host gifts. (That’s what the second jar is for.)

Read more »

[syndicated profile] designsponge_feed

Posted by Quelcy Kogel

Flowers are like a second language, a language which I have a hard time wrapping my brain and tongue around. Their exotic names often escape me, but I love to think of them like I think about paper or paint- materials to be sculpted or composed. Lauren Work Phillips is someone who can both speak flowers, as well as compose and sculpt them. She pours her passion into her blooms, from planting seeds at her family farm, to delivering painterly arrangements to events in the city. She’s one of the most passionate and energizing people to be around, which makes popping into her Pittsburgh brick-and-mortar all the more enticing.  

Lauren honed her floral skills working for Zuzu’s Petals, a flower shop in Brooklyn. She was surrounded and nurtured by other talented women who really loved flowers, so Lauren learned to appreciate, respect and care for every bloom she touched. Most importantly, she was encouraged to put herself into her work, and though she loved that work, she missed the simplicity and beauty of nature. Having grown up on a farm in Western Pennsylvania, she longed for dirt and fresh air, so she returned to nearby Pittsburgh with a strong vision to create a floral business rooted in her family’s farm.

Her vision also included a shop – a place to combine her floral services with plant-inspired gifts. The perfect location finally presented itself- a storefront in the historic Deutschtown neighborhood of Pittsburgh, and The Farmer’s Daughter Flowers was born. The space was a blank canvas – white walls and a subfloor, which Lauren and her husband Paul spent seven months transforming. The shop’s design had been such a long time coming. Lauren said, “The piece that we built the entire shop around was a 5’x7′ Dutch inspired floral painting. My husband bought it for me while we were still living in Brooklyn to put in my future flower shop.”

Today, shopper after shopper ‘grams that dramatic framed piece. It’d be easy to chalk up the shop to destiny, but “Work” is Lauren’s middle name after all. She has hustled hard and put her heart into her craft, and she takes nothing for granted. “The shop is filled with laughter, music, and coffee. I consider myself the luckiest to be surrounded by the most creative ladies and a wonderful husband on a daily basis. I am also so thankful for the clients/customers the shop attracts. We have created some wonderful relationships with wonderful people!” See what I mean? Don’t you just want to catch Lauren’s positive energy? You owe yourself a visit! –Quelcy

Photography by Quelcy.

Image Above: A wall in The Farmer’s Daughter Flowers showcases Lauren Works Phillips’ desire to combine dark, moody tones with lighter, whimsical products. 

(no subject)

Jun. 27th, 2017 10:47 am
yhlee: two voidmoths at war (hxx Raven Stratagem)
[personal profile] yhlee
An interview [Lightspeed Magazine] by Christian A. Coleman. Note that the interview mainly discusses Raven Stratagem, so there are spoilers for Ninefox Gambit. I also hint at what's coming in the third book, Revenant Gun.

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